Liquid Chromatography Tandem Mass Spectrometry Method for the Simultaneous Estimation of Telmisartan and Hydrochlorothiazide in Plasma
Abstract A rapid, sensitive and selective analytical Liquid chromatography tandem mass spectrometrymethod was developed and validated for the determination Telmisartan and Hydrochlorothiazidein human plasma. Liquid-liquid extraction was used for sample preparation and analysis, followed by liquid chromatography tandem spectrometric analysis and an electrospray-ionization interface. Compounds were analyzed on a Aquasil-C18 (250×4.6mm×5µm) column with the mobile…